Acylated pregnane glycosides from Caralluma sinaica

► NMR and UHPLC-TOF profiling of Caralluma sinaica reveal its complex pregnane composition. ► Six and seven known pregnanes were isolated from C. sinaica. ► A quinone reductase induction activity was shown for some pregnane glycosides. ► No relevant cytotoxicity was revealed for the C. sinaica extract.