Supercritical fluid extraction assisted isolation of sesquiterpene lactones with antiproliferative effects from Centipeda minima

► Supercritical fluid extraction was used to enrich low polar constituents. ► Six sesquiterpene lactones (1-6) along with seven known ones were isolated. ► Some compounds showed inhibitory activity against human nasopharyngeal cancer cells. ► Structure-relationships are discussed.