Cytotoxic triterpenoid saponins from Aesculus glabra Willd.

► Sixteen new saponins were isolated from the seeds of Aesculus glabra. ► Their structures provide chemotaxonomic evidence within the genus Aesculus. ► The saponins were cytotoxic against A549 and PC-3 cell lines (5.4 to >25 μM).