Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis

► Eight polyoxygenated cyclohexenes were isolated from Monanthotaxis congoensis. ► The compounds were isolated using a high-throughput natural products discovery approach. ► Structures were determined using NMR, MS, and optical rotation analyses. ► One compound displayed moderate antiproliferative activity against NCI-H460 and M14 cancer cells.