Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus

► Eighteen 9,19-cycloartane triterpenes, including ten new analogues were isolated and identified from Cimicifuga foetida. ► Three isolated triterpenoids exhibited moderate and broad-spectrum cytotoxicities against the testing human tumor cell lines. ► Based on the analysis of reported bioassay results, Preliminary structure-activity relationships for active compounds with a cimigenol-skeleton were proposed.