Sesquiterpene lactones from Vernonia scorpioides and their in vitro cytotoxicity

This paper reports isolation of sesquiterpene lactones (SL), luteolin, apigenin, and ethyl caffeate. The investigation of the SL in vitro cytotoxicity demonstrated that glaucolide 2 and hirsutinolide 4 were toxic to HeLa cells. Compounds 1/3 and 4 were also genotoxic in an in vitro comet assay.