Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae)

Phytochemical investigation of Symphonia globulifera (Clusiaceae) led to the isolation of nine polycyclic polyprenylated acylphloroglucinol compounds and two oxidized derivatives together with 7-epi-garcinol and 7-epi-isogarcinol. In vitro antiplasmodial assays revealed potent antimalarial activity for eleven of them. A LC/ESI-MSn study performed on polyprenylated benzophenones isolated previously provided a reliable method for their detection in the extract and structural elucidation.