Saponins and a lignan derivative of Terminalia tropophylla from the Madagascar Dry Forest

A study of an EtOH extract obtained from the roots of the Madagascan plant Terminalia tropophylla H. Perrier (Combretaceae) led to the isolation of the new oleanane-type triterpenoid saponin 1, the new lignan derivative 2, and the two known saponins arjunglucoside I and sericoside. Compound 1 showed antiproliferative activity against the A2780 human ovarian cancer cell line with an IC50 value of 1.2 μM.