Antiparasitic activity of prenylated benzoic acid derivatives from Piper species

Three prenylated hydroxybenzoic acids 3-[(2E,6E,10E)-11-carboxy-3,7,15-trimethyl-2,6,10,14-hexadecatetraenyl)-4,5-dihydroxy benzoic acid, 3-[(2E,6E,10E)-11-carboxy-13-hydroxy-3,7,15-trimethyl-2,6,10,14-hexadecatetraenyl]-4,5-dihydroxybenzoic acid and 3-[(2E, 6E,10E)-11-carboxy-14-hydroxy-3,7,15-trimethyl-2,6,10,15-hexadeca tetraenyl]-4,5-dihydroxy benzoic acid, along with six known compounds, were isolated from the leaves of Piper heterophyllum and P. aduncum. The compounds have been tested against three strains of Leishmania spp., Trypanosoma cruzi and Plasmodium falciparum.