Synthesis and cytotoxicity evaluation of natural α-bisabolol β-d-fucopyranoside and analogues

The natural α-bisabolol β-d-fucopyranoside (5b) as well as five analogues were efficiently synthesized in excellent yields (83-85%) using Schmidt's inverse procedure. α-Bisabolol α-l-rhamnopyranoside (6b) exhibited the strongest cytotoxic activity against cancer cell lines (IC50 40-64 μM).