Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity

Six pregnane glycosides were isolated from Caralluma tuberculata, including five ones (1-5). The structures of the isolated compounds were elucidated by the analysis of NMR data and FAB-MS experiments. All the isolated compounds were tested for their antimalarial and antitrypanosomal activities as well as their cytotoxicity against human diploid embryonic cell line (MRC-5).