Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum

Polyketides, leptosphaerone C (1), penicillenone (2), arugosin I (3) and 9-demethyl FR-901235 (4), were produced by the endophytic fungus Penicillium sp. Compounds 1 and 2 showed cytotoxicity against A-549 and P388 cells, respectively.