Biotransformation of 20(S)-protopanaxatriol by Mucor spinosus and the cytotoxic structure activity relationships of the transformed products

Microbial transformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus AS 3.3450 gave 10 metabolites. A possible biotransformation pathway was proposed and the in vitro cytotoxic activities of the metabolites against three human cancer cell lines were determined.