Constituents of the stem bark of Discopodium penninervium and their LTB4 and COX-1 and -2 inhibitory activities

A withanolide and a sesquiterpene lactone were isolated from the stem bark of Discopodium penninervium and tested in vitro against LTB4, COX-1 and -2. The withanolide (1) demonstrated significant inhibitory effect against LTB4 and selectivity for COX-2 inhibition.