Biologically active tetralones from New Caledonian Zygogynum spp.

Four phenyl-3-tetralones (1-4) were isolated from the bark and leaves of various species of Zygogynum (Winteraceae). The structures were elucidated by extensive mono- and bi-dimensional spectroscopy. They exhibited binding affinity for peroxisome proliferator-activated receptor (PPAR-γ).