Antifungal and antioxidant activities of the phytomedicine pipsissewa, Chimaphila umbellata

Demonstration of antifungal and antioxidant effects supports the traditional use of pipsissewa in treating skin ailments. Chemical-genetic profiling with a library of yeast deletion mutants indicated that the principal antifungal constituent, chimaphilin, had a complex mode of action, affecting a protein-protein interaction network including 26% of the genes in the profile.