Resolution of diastereomeric flavonoid (1S)-(−)-camphanic acid esters via reversed-phase HPLC

Diastereomeric tri-(1S)-(−)-camphanic acid esters of the 4′,5,7-trihydroxy flavanones naringenin, 8-prenylnaringenin and 6-prenylnaringenin were formed. The respective diastereomers were separated using analytical reversed-phase HPLC, isolated by preparative HPLC to >98% d.e. based on HPLC, with absolute configurations established by application of CD spectrometry.