Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx

The roots of Hovea parvicalyx yielded 2′-methoxy-3′-prenyl-licodione (1) and 2′-methoxy-3′,3′′-diprenyl-licodione (2), two prenylated β-hydroxychalcone compounds, together with the known flavanone (S)-glabrol (3). These compounds showed Icmt inhibitory activity.