Cytotoxic and apoptosis-inducing effect of ent-15-oxo-kaur-16-en-19-oic acid, a derivative of grandiflorolic acid from Espeletia schultzii

ent-Kaurenic acid and many natural derivatives of this diterpene are known to have interesting biological properties. ent-15-oxo-kaur-16-en-19-oic acid (EOKA), obtained from grandiflorolic acid from Espeletia schultzii, induces changes in the expression level of proteins associated with the execution and regulation of apoptosis on the human prostate carcinoma epithelial cell line PC-3.