Inhibition of MMP-2 secretion from brain tumor cells suggests chemopreventive properties of a furanocoumarin glycoside and of chalcones isolated from the twigs of Dorstenia turbinata

Antitumerogenic properties of compounds isolated from the twigs of Dorstenia turbinata were evaluated through the inhibition of matrix metalloproteinase (MMP)-2 secretion from human U87 glioblastoma cells. Among the compounds isolated, a furanocoumarin glycoside, named turbinatocoumarin (1), together with eight known compounds, were shown possess inhibitory properties as potent as those of the chemopreventive and naturally occurring MMP secretion inhibitors chlorogenic acid and epigallocatechin-3-gallate.