Activity-guided isolation of antiplasmodial dihydrochalcones and flavanones from Piper hostmannianum var. berbicense

Four dihydrochalcones were isolated from the leaves of Piper hostmannianum var. berbicense with the known dihydrochalcones 2′,6′-dihydroxy-4′-methoxydihydrochalcone, adunctin E and (−)-methyllinderatin together with linderatone and strobopinin. All isolated compounds were evaluated for their antiplasmodial and cytotoxic activities against Plasmodium falciparum and MCF-7 cells.