Homoisoflavanones from Disporopsis aspera

Four homoisoflavanones along with six other known compounds were isolated from cytotoxic extracts of the rhizome of Disporopsis aspera. Structures of 1-2 were established on the basis of spectral evidence. The isolated homoisflavanones inhibit the proliferation of several cancer human cell lines i.e. HCT15, T24S, MCF7, Bowes, A549 and K562. Possible biosynthesis routes for the homoisoflavonoids are discussed.