Antiproliferative activity of steroidal saponins from Balanites aegyptiaca-An in vitro study

► From Balanites aegyptiaca Del, four known spirostane and furostane saponins were isolated. ► Among the 4, SAP-1016 (1) showed potent anti-proliferative activity against human cancer cells. ► SAP-1016 also demonstrated apoptosis activation and reactive oxygen species (ROS) generation.