Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)

A new stigmastane steroid; 3,4-epoxy-(22R,25)-tetrahydrofuran-stigmast-5-en (1), along with two known triterpenes, dammara-20,25-diene-3β,24-diol (2), dammara-20S,5α,24-en,3β,20-diol (3) and two known steroids, stigmast-5-ene-3β,4β-diol (4), stigmasterol 3-O-β-d-glucoside (5) were isolated from the bark of Aglaia eximia. Compounds 2 showed strongest cytotoxicity against P-388 murine leukemia cells with IC50 values of 4.26 μg/mL.