A novel cytotoxic aryltetraline lactone from Bupleurum marginatum (Apiaceae)

► A detailed phytochemical study of the aerial parts extract led to isolation and characterization of 15 compounds. ► A new aryltetraline lactone lignan was identified as marginatoxin. ► The cytotoxic activity of the isolated compounds in both HepG2 and HeLa cancer cell lines are reported.