Dihydroisocoumarins produced by Xylaria sp. and Penicillium sp., endophytic fungi associated with Piper aduncum and Alibertia macrophylla

► Fungal endophytes are a remarkable source of bioactive natural products. ► Two endophytes, Xylaria sp. and Penicillium sp., have been isolated. ► Both endophytes produced one new and two known dihydroisocoumarins. ► The isolated dihydroisocoumarins displayed antifungal and AChE inhibitory activities.