In vitro hydroxylation of a norlignan: From agatharesinol to sequirin C and metasequirin C with a microsomal preparation from Cryptomeria japonica

In vitro hydroxylation of norlignan from agatharesinol to sequirin C and metasequirin C was demonstrated for the first time. After incubating agatharesinol with a microsomal preparation from the heartwood side of the intermediate wood of Cryptomeria japonica in the presence of cofactors, sequirin C and metasequirin C were formed.