کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5177361 | 1380857 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fluorinated and rearranged gedunin derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Fluorinated and rearranged gedunin derivatives Fluorinated and rearranged gedunin derivatives](/preview/png/5177361.png)
چکیده انگلیسی
When treated with (diethylamino)sulfur trifluoride (DAST), 11α-hydroxygedunin gave 11β-fluorogedunin and 9,11-didehydrogedunin, whereas deacetylgedunin afforded two skeletal rearranged products 6 and 7, in which the Me-30 had shifted from position 8 to position 7. Of those products, 11β-fluorogedunin and 6 were shown to be more cytotoxic than gedunin on P-388 leukemia cells.
Highlights⺠A fluorinated gedunin derivative was prepared from 11α-hydroxygedunin. ⺠A skeletal rearrangement reaction occurred when deacetylgedunin was treated with DAST. ⺠The structure of the rearranged product was established by X-ray crystallography. ⺠Some analogs were found to be more cytotoxic than gedunin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytochemistry Letters - Volume 5, Issue 3, September 2012, Pages 486-489
Journal: Phytochemistry Letters - Volume 5, Issue 3, September 2012, Pages 486-489
نویسندگان
Yukio Hitotsuyanagi, Kumiko Mitsui, Haruhiko Fukaya, Koichi Takeya,