Bioactive styryllactones, two new naphthoquinones and one new styryllactone, and other constituents from Goniothalamus scortechinii

Two new naphthoquinones, goniothalaminone A (1) and B (2), and a new styryllactone, (−)-8-epi-9-deoxygoniopypyrone acetate (12) together with one known naphthoquinone (3), one known indolequinone (4), one known 1-azaanthraquinone (5), six known styryllactones (6-11) and one known sesquiterpene (13) were isolated from the roots and leaves of Goniothalamus scortechinii. The structures of the new compounds were elucidated by spectroscopic analysis and of the known compounds by comparison of their physical, UV, IR, 1H and 13C NMR data with those of published compounds. Antiplasmodial, antimycobacterial and cytotoxic activities of the styryllactones were evaluated. Compounds 6-10 exhibited cytotoxic against human cancer cell lines, KB, BC and NCI-H187 with IC50 values ranging from 0.13 to 11.7 μg/ml.

Two new naphthoquinones, goniothalaminone A (1) and B (2), and a new lactone, (−)-8-epi-9-deoxygoniopypyrone acetate (12) together with ten known compounds were isolated from Goniothalamus scortechinii. The structures of new compounds were elucidated by spectroscopic analysis and the known compounds were comparison of their physical, UV, IR, 1H and 13C NMR data with those already published. Antiplasmodial, antimycobacterial and cytotoxic activities of the styryllactones were evaluated.Highlights► Two new naphthoquinone derivatives 1 and 2, and the new lactone derivative 12 were isolated from Goniothalamus scortechinii. ► The structure elucidation by the use of spectroscopic methods including UV, IR, HR-TOF-MS, 1D and 2D NMR. ► Antiplasmodial, antimycobacterial and cytotoxic activities of the styryllactones were evaluated.