کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5184045 1381037 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functionalization of microspheres with malonates using Michael Addition as a pathway to create a drug delivery system for platinum drugs for the treatment of liver cancer
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Functionalization of microspheres with malonates using Michael Addition as a pathway to create a drug delivery system for platinum drugs for the treatment of liver cancer
چکیده انگلیسی

Microspheres have been modified post-polymerization via Michael Addition to suit the requirement of these beads as a drug delivery carrier for platinum drugs. Ethyleneglycol dimethacrylate (EGDMA) was polymerized in a suspension system leading to microspheres with an excess of vinyl functionalities. Solid state NMR was employed to determine the amount of repeating groups with unreacted vinyl groups and a molar ratio of 28% was obtained. The percentage of vinyl groups was approximately confirmed using FT-Raman (34%). Subsequent Michael Addition of these vinyl functionalities with diethyl malonate leads to modification of almost half of the vinyl groups. Ester hydrolysis and reaction with cisplatin (cis-diammineplatinum(II) dichloride) lead to microspheres with a loading of around 9 wt% of platinum. The platinum drug was slowly released at a rate of 20% in 10 days making these microspheres suitable for the treatment of liver cancer via transarterial chemoembolization. Indeed, the drug-loaded carrier was found to be highly toxic to liver cancer cells (ATCC, HepG2) while the empty carrier is non-toxic.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 52, Issue 26, 13 December 2011, Pages 5993-6002
نویسندگان
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