کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5185564 | 1381081 | 2010 | 9 صفحه PDF | دانلود رایگان |
Polyvinyl alcohol (PVA) nanofibers, PVA/Type I Collagen (Col) and their composites with hydroxyapatite nanoparticles (nano-HAp) were prepared by electrospinning techniques. The composite nanofibrous membranes were subjected to detailed analysis. Morphological investigations show that the generated nanofibers (NFs) have uniform morphology with an average diameter of â¼160 nm for pure PVA, â¼176 nm for PVA/n-HAp, â¼245 nm for PVA/Col and â¼320 nm for PVA/Col/n-HAp. It is of interest to observe that large numbers of HAp nanorods are preferentially oriented parallel to the longitudinal direction of the electrospun PVA and/or PVA/Col NFs. FTIR and thermal analysis demonstrated that there was strong intermolecular hydrogen bonding between the molecules of PVA/Col/n-HAp. Furthermore, the obtained PVA/Col/nHAp NFs scaffold (7 cm Ã 11 cm) has a porous structure with adjustable pore size and shape. The pore size is in the range of 650 μm with a porosity of 49.5%. On the other hand, mechanical characterizations revealed that the incorporating of 5 wt% n-HAp into the matrix of PVA/Col nanofibers could significantly improve the rigidity of the resultant biocomposite nanofibrous scaffold. These results strongly suggest a huge potential of the prepared scaffold for bone tissue engineering.
Journal: Polymer - Volume 51, Issue 4, 15 February 2010, Pages 868-876