کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5186675 | 1381111 | 2006 | 5 صفحه PDF | دانلود رایگان |
A combined enzymatic resolution and chemical polymerization strategy has been used to create optically active polymeric prodrugs. (S)-Naproxen, (S)-ketoprofen and (S)-ibuprofen derivatives were obtained in excellent optical purity and high yield by enzymatic resolution after optimization of reaction conditions. Each optically active monomer was subjected to free radical polymerization with methyl methacrylate. The obtained optically active polymeric prodrugs bearing (S)-naproxen, (S)-ketoprofen or (S)-ibuprofen residue were characterized by IR, NMR and GPC. The effect of molar ratio of naproxen vinyl ester to methyl methacrylate on the polymerization was also investigated. This methodology is useful to provide a facile and clean route to optically active macromolecular prodrugs.
Journal: Polymer - Volume 47, Issue 19, 7 September 2006, Pages 6491-6495