Interaction of poly(N-acryloyl-amino acids) with saccharides in aqueous media

The interaction of a series of poly(N-acryloyl-amino acids) (pAXaa) with saccharides has been investigated by 1H NMR. 1H NMR for methyl-β-d-galactopyranoside (MβGal) in the presence of pAXaa indicated that hydrophobic interaction or hydrogen bonding was not considerable in the interaction of the polymers with MβGal in aqueous media whereas CH-π interaction was relatively important. 1H NMR for several saccharides in the presence of poly(N-acryloyltryptophan) (pATrp) indicated that pATrp interacted more strongly with the β-anomers than with the α-anomers presumably because of the triple CH-π interactions of the three axial protons in the β-anomers. In the interaction of pATrp with MβGal, MβGal interacted with two or more Trp residues because Trp residues were localized on the polymer chain.