کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5187476 1381131 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Crosslinking of cellulose derivatives and hyaluronic acid with water-soluble carbodiimide
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Crosslinking of cellulose derivatives and hyaluronic acid with water-soluble carbodiimide
چکیده انگلیسی

Hydrogels with good mechanical stability are generally obtained by chemical crosslinking. However, the compounds used as crosslinking agents are often highly toxic, and thus they are not recommended as starting materials in view of an environmentally safe production process and a biocompatible product.In this work chemically crosslinked superabsorbent hydrogels have been synthesized from water solutions of hydroxyethylcellulose (HEC), carboxymethylcellulose sodium salt (CMCNa) and hyaluronic acid (HA), using a non-toxic water-soluble carbodiimide (WSC) as crosslinking agent. Sorption capacity both in water and in water solutions at different ionic strength has been investigated, taking into account the effect of different chemical compositions. Moreover, uniaxial compression tests and dynamic-mechanical measurements on water swollen samples have been performed to probe the elastically effective degree of crosslinking of the polymeric network.In vivo tests on humans for the application of this material as a bulking agent in dietary regimes are in process and preliminary results are encouraging.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 46, Issue 25, 28 November 2005, Pages 11206-11212
نویسندگان
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