کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5188947 1381173 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro degradation and biocompatibility of poly(l-lactic acid)/chitosan fiber composites
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
In vitro degradation and biocompatibility of poly(l-lactic acid)/chitosan fiber composites
چکیده انگلیسی
In this study, poly(l-lactic acid) (PLLA) fibers were prepared by the dry-wet-spinning method, while chitosan (CHS) fibers were prepared via the wet-spinning method. The two fibers were blend spun and then fabricated into PLLA/CHS fabrics. In vitro degradation experiments of the fabrics were carried out in a phosphate-buffered solution at 37 °C with a pH of 7.4. Changes in molecular parameters (molecular weights and molecular weight distributions), phase structures (crystallinities), morphologies (fiber surface topologies) of the PLLA fibers, and their macroscopic properties (the fabric weight losses and mechanical strengths) were monitored with degradation times. These results were compared with control samples with no degradation. The hydrolysis mechanism of PLLA/CHS fabrics was analyzed. It was found that the degradation rate of dry-wet-spun PLLA fibers was higher than those of the melt-spun or dry-spun ones. Furthermore, the compatibility between PLLA/CHS fabrics and osteoblast under the in vitro degradation was investigated for the potential application of using the PLLA/CHS fabrics as supporting materials for chest walls and bones. Cell strain hFOB1.19 human SV40-transfected osteoblast and PLLA/CHS mixed fabrics were incubated. The cell morphology at early stages of cultivation was also studied. Excellent adhesion between osteoblast and PLLA/CHS fabrics was observed, indicating good biocompatibility of the fabrics with osteoblast.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 48, Issue 4, 9 February 2007, Pages 1005-1011
نویسندگان
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