کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5200750 | 1502869 | 2017 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Poly(methacrylated hyaluronan-co-ethyl acrylate) copolymer networks with tunable properties and enzymatic degradation
ترجمه فارسی عنوان
شبکه های کوپلیمر پلی (متاکریلیت هیالورونان - اتیل اکریلات) با خواص قابل تنظیم و تخریب آنزیمی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Semi-biodegradable copolymer networks derived from two immiscible components, a hyaluronan derivative (methacrylated hyaluronan) and poly(ethyl acrylate), have been developed for soft tissue engineering applications. These copolymer networks combine the hydrogel-like properties of hyaluronan networks with the rubber-like behavior and low water uptake of the poly(ethyl acrylate) networks. In order to copolymerize hyaluronan and ethyl acrylate, a hyaluronan derivative containing vinyl groups was first obtained. In spite of the different nature of both polymers, the variation of the weight fraction of ethyl acrylate in the copolymerization yields copolymer networks with co-continuity of phases, and tunable swelling degree and mechanical properties. In addition, the MeHA chains are susceptible of being enzymatically degraded, and the resulting materials are mainly composed of a PEA framework with structural integrity. These copolymers networks are good candidates to assist the regeneration process of soft tissues when longer residence times are required.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 144, October 2017, Pages 241-250
Journal: Polymer Degradation and Stability - Volume 144, October 2017, Pages 241-250
نویسندگان
Manuel Pérez-Garnes, Manuel Monleón-Pradas,