کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5202450 | 1381900 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of porosity on long-term degradation of poly (ε-caprolactone) scaffolds and their cellular response
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Porous poly(ε-caprolactone) (PCL) scaffolds are widely used as in vivo implants in tissue engineering, and their long-term degradation behaviors are of great importance for their in vivo performances. However, the influence of porosity on long-term degradation of PCL scaffold in phosphate buffer solution (PBS) has been rarely reported so far. Herein, a 72-week degradation study of PCL scaffolds with various porosities was conducted to elucidate the changes of physico-chemical properties such as weight, molecular weight, morphology and compressive modulus. Within 72 weeks, PCL scaffolds experienced three stages: stable stage, mechanical loss stage and structural collapse stage. The higher porosity induced the severer loss of weight, molecular weight and compressive modulus. It was found that a minimal acid autocatalysis also happened in the scaffold samples with low porosities (less than 85%). Cellular response on the scaffolds with various porosities was further evaluated. The cell ingrowth improved on the scaffold with high porosity (e.g. S-10) in contrast to those with low porosity (e.g. S-6 and S-4). The combined results demonstrated that an optimal porosity of PCL scaffolds should be designed greater than 90% due to the appropriate degradation rate and good cell performance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 98, Issue 1, January 2013, Pages 209-218
Journal: Polymer Degradation and Stability - Volume 98, Issue 1, January 2013, Pages 209-218
نویسندگان
Qingchun Zhang, Yun Jiang, Yan Zhang, Zhaoyang Ye, Wensong Tan, Meidong Lang,