کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5203169 1381923 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physicochemical characterisation of degrading polycaprolactone scaffolds
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Physicochemical characterisation of degrading polycaprolactone scaffolds
چکیده انگلیسی
A degradation study investigating the hydrolysis of different scaffolds of polycaprolactone suspended in phosphate buffer solution at 37 °C was performed over a three month period. Structures included electrospun fibres, held as 2D mats and 3D bundles, and solvent cast films. These structures and their surrounding solutions were physiochemically characterised using a range of techniques. Changes in scaffold physicochemical properties were observed over the course of the study, including significant loss in molecular mass, increases in thermal properties and crystallinity, and increases in tensile properties. The presence of degradation products, such as capronic acid containing compounds was also identified in the surrounding solution. 3D electrospun bundles - as a consequence of being the least crystalline scaffold and hence most susceptible to hydrolysis - demonstrated greatest reduction in molecular mass over the three months, followed by 2D electrospun mats, and the lowest mass loss was observed for solvent cast films.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 95, Issue 12, December 2010, Pages 2269-2276
نویسندگان
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