Degradation of poly(vinyl chloride) plasticized with non-phthalate plasticizers under sterilization conditions

Plasticized PVC formulations have traditionally been used in the production of medical devices, such as tubes and bags for plasma or blood because of their good performance in mechanical and thermal properties as well as their low cost. Clinical practice, in particular re-use after sterilization, can damage and promote degradation of these materials with the risk of release of polymer additives into physiological fluids and consequently risks to patient's health. Formulations with commercial plasticizers, alternative to traditional phthalates (citrate and carboxylate compounds) have been proposed in this work and their behaviour after repeated sterilization has been evaluated. Structural, mechanical, thermal and surface properties have been tested and no significant degradation was observed. No apparent risk of massive damage to plasticized PVC could be considered after repeated sterilization.