کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5208829 1382613 2008 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymeric nanomedicine for cancer therapy
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Polymeric nanomedicine for cancer therapy
چکیده انگلیسی

Nanomedicine, an offshoot of nanotechnology, refers to highly specific, molecular-scale medical intervention for treating disease or repairing damaged tissues. In recent years, polymer-based nanomedicine, a field that includes the use of polymer-DNA complexes (polyplexes), polymer-drug conjugates, and polymer micelles bearing hydrophobic drugs, has received increasing attention for its ability to improve the efficacy of cancer therapeutics. Owing to their small size and excellent biocompatibility, nanosized polymer therapeutic agents can circulate in the bloodstream for long periods of time, allowing them to reach the target site. In addition, chemical modification of polymer therapeutic agents with ligands capable of specifically binding receptors that are over-expressed in cancer cells can markedly augment therapeutic efficiency. This review highlights the characteristics of cancer that provide nanodrug targeting opportunities and discusses rational approaches for future development of polymeric nanomedicines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Polymer Science - Volume 33, Issue 1, January 2008, Pages 113-137
نویسندگان
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