کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5209008 | 1503019 | 2007 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Emerging applications of polymersomes in delivery: From molecular dynamics to shrinkage of tumors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Polymersomes are self-assembled shells of amphiphilic block copolymers that are currently being developed by many groups for fundamental insights into the nature of self-assembled states as well as for a variety of applications. While recent reviews have highlighted distinctive properties-particularly stability-that are strongly influenced by both copolymer type and polymer molecular weight, here we first review some of the more recent developments in computational molecular dynamics (MD) schemes that lend insight into assembly. We then review polymersome loading, in vivo stealthiness, degradation-based disassembly for controlled release, and tumor shrinkage in vivo. Comparisons of polymersomes with viral capsids are shown to encompass and inspire many aspects of current and emerging designs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Polymer Science - Volume 32, Issues 8â9, AugustâSeptember 2007, Pages 838-857
Journal: Progress in Polymer Science - Volume 32, Issues 8â9, AugustâSeptember 2007, Pages 838-857
نویسندگان
Dennis E. Discher, Vanessa Ortiz, Goundla Srinivas, Michael L. Klein, Younghoon Kim, David Christian, Shenshen Cai, Peter Photos, Fariyal Ahmed,