کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5209016 1503019 2007 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymers for bioimaging
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Polymers for bioimaging
چکیده انگلیسی

Many imaging techniques, such as optical imaging, magnetic resonance imaging, nuclear imaging, and ultrasound have been successfully utilized in clinical applications for the past decades. However, there is an urgent need to design new bioimaging probes because imaging of specific molecular pathways in vivo, particularly those that play key roles in disease processes, is hampered by the poor sensitivity and specificity with current low molecular weight imaging compounds. Recently, interdisciplinary research at the interface of polymer chemistry and the bioimaging sciences has led to the generation of polymer-based bioimaging probes for the diagnosis and treatment of disease. A combination of imaging modality and several biocompatible and/or biodegradable synthetic and natural polymers such as multivalent, branched, graft, and block copolymers, polysaccharides and dendrimers, has produced bioimaging probes which have prolonged plasma half-lives, enhanced stability, reduced toxicity, and improved target specificity. Bioimaging facilitates the integration of complex biological phenomena into the rapid visualization process in molecular levels, and are extending the applications into therapy and high throughput drug screening. This review describes the current advances in polymers for bioimaging and highlights their potentials in clinical applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Polymer Science - Volume 32, Issues 8–9, August–September 2007, Pages 1031-1053
نویسندگان
, , , , , ,