کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5209676 1503064 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
l-ascorbic acid modified poly(ester urethane)s as a suitable candidates for soft tissue engineering applications
ترجمه فارسی عنوان
ال-اسکوربیک اسید اصلاح شده پلی (اوره اتر) به عنوان یک کاندید مناسب برای برنامه های مهندسی بافت نرم
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
In this paper we created novel poly(ester urethane)s (PESUs) designed specifically for tissue engineering. The PESUs were derived from oligomeric α,ω-dihydroxy(ethylene-butylene adipate) (dHEBA), 1,4-butanediol (BDO) and aliphatic 1,6-hexamethylene diisocyanate (HDI) and modified with l-ascorbic acid to improve their biocompatibility. In addition, we determined their mechanical properties (such as tensile strength, elongation at break and hardness). To determine how these materials may potentially behave after implementation in tissue, we estimated the degradation behavior of obtained PESUs in various chemical environments, which were exemplified by canola oil, saline solution, distilled water and phosphate buffered saline (PBS). Finally, the PESU biocompatibility and hemocompatibility tests were carried out. Biocompatibility was determined with a MTT assay and it was performed with 3T3 cell line. The results showed satisfactory mechanical properties, good hemocompatibility and improved biocompatibility, which let us to conclude that PESUs modified with ascorbic acid might find an application in biomedical field of soft tissues engineering.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 97, December 2015, Pages 105-115
نویسندگان
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