کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210431 | 1382893 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: pH-responsive magnetic mesoporous silica nanospheres for magnetic resonance imaging and drug delivery pH-responsive magnetic mesoporous silica nanospheres for magnetic resonance imaging and drug delivery](/preview/png/5210431.png)
Multi-functional magnetic mesoporous silica nanospheres (MMSNs), which were coated with poly(acrylic acid) (PAA), have been synthesized using the atom transfer radical polymerization of tert-butyl acrylate on the surface of MMSNs followed by the hydrolysis of the grafted poly(tert-butyl acrylate) chains. The resulting MMSN-PAA nanocomposites exhibit negligible cytotoxicity toward HeLa and L02 cells. Magnetic resonance imaging (MRI) studies reveal that the nanocomposites can be effectively taken-up by the cancer cells. The anticancer drug doxorubicin hydrochloride (DOX) can be loaded into the nanocomposites and subsequently released in a sustained and pH-responsive way because of the presence of pH-sensitive polymer shells. The DOX-loaded nanocomposites exhibit notable cytotoxicity to HeLa cancer cells. These results demonstrate that the pH-responsive MMSN-PAA nanocomposites can be applied to biological systems for MRI and drug delivery.
Journal: Reactive and Functional Polymers - Volume 72, Issue 5, May 2012, Pages 329-336