کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210449 | 1382894 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and self-assembly of biomimetic phosphorylcholine-bound chitosan derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and self-assembly of biomimetic phosphorylcholine-bound chitosan derivatives Synthesis and self-assembly of biomimetic phosphorylcholine-bound chitosan derivatives](/preview/png/5210449.png)
چکیده انگلیسی
Biomimetic N-phosphorylcholine (PC)-chitosan derivatives (PCCs) with a phosphoramide linkage between glucosamine and PC in various degree of substitution (DS) were synthesized through Atherton-Todd reaction and subsequently hydrolysis under the mild conditions, and structurally characterized by 1H NMR, 31P NMR, FT-IR and GPC. The incorporation of zwitterionic PC groups modified the hydrophilic/hydrophobic balance of chitosan derivatives to induce the formation of nanosized micelles by self-assembly in neutral aqueous solution. Fluorescence measurements revealed that the critical aggregation concentration (CAC) of PCCs solutions increased with increasing the DS of PC. The physicochemical properties of PCCs aggregates in neutral aqueous solutions were investigated by AFM and dynamic light scattering (DLS). The results confirmed that the amphiphilic PCCs copolymers can self-assemble to form nanosized spherical micelles with zeta potential between 0 and 4Â mV, suggesting that the PCCs nano-aggregates were mostly covered with electrically neutral zwitterionic PC groups. Furthermore, all the PCCs samples showed low toxicity against NIH/3T3 cells after incubated for 4Â h or 24Â h, indicating their safety for biomedical application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 72, Issue 10, October 2012, Pages 745-751
Journal: Reactive and Functional Polymers - Volume 72, Issue 10, October 2012, Pages 745-751
نویسندگان
Rong Zeng, Kai Guo, Zehu Wang, Mei Tu, Jianhao Zhao, Ju Wang,