کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5211595 | 1382958 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of hepatocyte behaviors by galactose-carrying polymers through receptor-mediated mechanism
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
In liver tissue engineering, the development of appropriate extracellular matrix (ECM) is important because hepatocytes are anchorage-dependent cells and they rapidly lose liver-specific functions and viability in vitro. Therefore, it is very important to regulate galactose-mediated hepatocyte recognition to enhance selective interactions between galactose-carrying polymers and hepatocytes and liver-specific functions. In this review, to regulate hepatocyte behaviors by galactose-carrying polymers, the effect of physico-chemical properties of galactose-carrying polymers, cellular environment, medium composition and dynamic culture system were explained. Moreover, to understand the regulation mechanism of hepatocyte behaviors by galactose-carrying polymers, intracellular signal transduction in the hepatocytes by galactose-carrying polymers was also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 67, Issue 11, November 2007, Pages 1301-1310
Journal: Reactive and Functional Polymers - Volume 67, Issue 11, November 2007, Pages 1301-1310
نویسندگان
C.S. Cho, T. Hoshiba, I. Harada, T. Akaike,