کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5211596 | 1382958 | 2007 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, characterization, and biomedical applications of core-shell-type stimuli-responsive nanogels - Nanogel composed of poly[2-(N,N-diethylamino)ethyl methacrylate] core and PEG tethered chains
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We present a review of stimuli-responsive smart PEGylated nanogels and their biomedical applications. We describe the synthesis and characterization of stimuli-responsive PEGylated nanogels composed of a cross-linked poly[2-(N,N-diethylamino)ethyl methacrylate] (PDEAMA) core and PEG tethered chains that bear a carboxylic acid group as a platform moiety for the installation of bio-tags. In addition, PEGylated nanogels show unique properties and functions in synchronizing with the reversible volume phase transition of the PDEAMA core in response to various stimuli, such as pH, ionic strength and temperature. We list some of the biomedical applications of the nanogels, including endosomolytic agents for nonviral gene delivery, drug delivery carriers, nanoreactors, and skin-specific nanocatalysts for reactive oxygen species (ROS).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 67, Issue 11, November 2007, Pages 1311-1329
Journal: Reactive and Functional Polymers - Volume 67, Issue 11, November 2007, Pages 1311-1329
نویسندگان
Motoi Oishi, Yukio Nagasaki,