کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5211659 | 1382964 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers](/preview/png/5211659.png)
چکیده انگلیسی
Novel polyelectrolyte beads based on carboxymethyl Konjac glucomannan (CKGM) and chitosan (CS) were prepared via electrostatic interaction. The main advantage of this system is that all procedures used were performed in aqueous medium. The pH-sensitivity of beads was characterized by fourier transformed infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). The swelling characteristics of these hydrogel beads at distinct compositions as a function of pH values were investigated. It was found that the swelling rate of test beads was larger (7.4) in the alkaline medium than in the acid medium (5.2) and at pH 5.3 was the smallest (3.5). Furthermore, for the evaluation of the pH effect on drug release from the beads, we studied bovine blood proteins (BSA) release profiles at pH 1.2, 5.0 and 7.4. The pH-sensitivity of the novel polyelectrolyte complex would make an interesting protein delivery system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 66, Issue 10, October 2006, Pages 1055-1061
Journal: Reactive and Functional Polymers - Volume 66, Issue 10, October 2006, Pages 1055-1061
نویسندگان
Jian Du, Jing Dai, Jun-Long Liu, Theresa Dankovich,