کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5211918 | 1383095 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
N-heterocyclic carbene-mediated formal [3+3] annulation of isatin-derived α, β-unsaturated acids: Access to functionalized 3,4â²-spirooxindole δ-lactones
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: N-heterocyclic carbene-mediated formal [3+3] annulation of isatin-derived α, β-unsaturated acids: Access to functionalized 3,4â²-spirooxindole δ-lactones N-heterocyclic carbene-mediated formal [3+3] annulation of isatin-derived α, β-unsaturated acids: Access to functionalized 3,4â²-spirooxindole δ-lactones](/preview/png/5211918.png)
چکیده انگلیسی
An in situ activation of isatin-derived α,β-unsaturated acids 2 for the generation of isatin-derived α,β-unsaturated acyl azoliums II was described. The acyl azoliums II were successfully applied to undergo a formal [3 + 3] annulation with 1,3-dicarbonyl compounds to access functionalized 3,4â²-spirooxindole δ-lactones 4. A scale-up synthesis and an enantioselective variant of this protocol were also investigated. The stable and easily prepared acids 2 may be further utilized as promising versatile electrophilic 1,3-synthons for divergent synthesis of spirooxindoles.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 73, Issue 23, 8 June 2017, Pages 3249-3254
Journal: Tetrahedron - Volume 73, Issue 23, 8 June 2017, Pages 3249-3254
نویسندگان
Weiguo Zhang, Junyu Xu, Jing Cao, Chao Fang, Jindong Zhu, Tao Lu, Ding Du,