Asymmetric ortho-deprotonation of (η6-arene) chromium tricarbonyl complexes substituted with a chiral hydroxylamine

The use of O-methyl-N-(α-methylbenzyl)hydroxylamine as a novel chiral auxiliary in asymmetric ortho-deprotonation of the (η6-arene) chromium tricarbonyl complexes is described. Upon quenching of the resultant ortho-lithiated complex with an electrophile, 1,2-disubstituted (η6-arene) chromium tricarbonyl complexes were obtained in good yield and excellent levels of diastereoselectivity.

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